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Research Portfolio

Adore challenges conventional research paradigms by adopting a multidisciplinary approach that transcends traditional disease-specific frameworks. Rather than studying diseases solely within the confines of a single discipline—such as neurology or oncology—Adore fosters a broader, integrative perspective that encourages groundbreaking ideas beyond traditional scientific boundaries.

Currently, six out of seven focus groups are actively managing projects, each overseeing between one and three initiatives. Project funding ranges from €20,000 to €2,5 million, with additional investments in the pipeline.

Our funding strategy is designed to support both strong research infrastructure and cutting-edge innovation. Looking ahead, we will place greater emphasis on a “high-risk, low-cost” approach to accelerate implementation, foster breakthrough ideas, and maximize impact. At the same time, “low-risk, high-cost” proposals with strong innovation potential and high expected impact remain welcome.

The Dutch Research Council (NWO) has awarded Adore €9 million as part of its €25 million KIC-LTP funding initiative, which aims to address pressing societal challenges such as the rising rates of cancer and neurodegenerative diseases in the Netherlands. With this support, Adore is launching a 10-year, €30 million interdisciplinary research program. The program brings together public and private partners, including Vrije Universiteit Amsterdam, Leiden University Medical Center, UMC Utrecht, TU Delft and OMAPiX. Leading experts from oncology, neurology, data science, and ethics are united in this unique collaboration, supported by a dedicated research facility and significant private funding. Through this consortium, Adore stimulates the development of new therapies, diagnostic tools, and precision medicine.

Below, you will find an overview of previously funded projects and their details. Proposals that are currently under review are also higlighted.

Project nameFocus groupBrief descriptionTime-lineBudget
CRISPR – Cut to the ChaseProteomics & GenomicsThis project aims to accelerate both cancer and brain research using cutting-edge CRISPR technology.May 2024 – May 2029€748.000
EV-PREDICTEV-PREDICT
Proteomics & Genomics
The aim of this project is to further improve the use and the interpretation of cerebrospinal fluid (CSF) biomarkers as predictors of disease pathogenesis and to use that information to develop precision medicine for heterogeneous brain disorders.November 2024 – November 2028€1.220.000
TRANSVISION
Proteomics & Genomics
This project aims to establish a novel approach for multi-cell type disease modeling and set-up CRISPR screening for new therapeutic targets involved in neuron-tumor and glia-tumor interactions.April 2025 – April 2029€1.837.000
BioDORABiobanking & BiomarkersThe overall objective of this project is to develop BioDORA as an Amsterdam infrastructure facilitating access to, and mining of clinical variables and biomaterials of patient cohorts and age-matched healthy individuals.November 2024 – November 2029€988.000
Gen-BioDORABiobanking & BiomarkersWith the GEN-BioDORA project we centralize storage of virtual patient materials (liquids and tissues) for Adore research use and reuse with back-ups.September 2024 – September 2028€988.000
Crossing barriersImagingThis proof-of-concept study will assess whether we can measure the brain delivery and distribution of TILs and mAbs in patients with Positron Emission Tomography (PET) imaging.June 2025 – June 2030€1.052.000
Crossing barriersImmuno- & Cellular therapyThe overall aim of this project is to define how the brain microenvironment controls immune cell infiltration into the CNS during health (healthy age continuum, incl 100-plus cohort) and in the neurological disorders multiple sclerosis (MS) and Alzheimer’s disease(AD) and the oncological disorder glioblastoma (GBM) and brain metastatic lung tumours and melanoma.September 2024 – September 2028€1.099.000
NICITAImmuno- & Cellular therapyThe aim of this project is to characterize common and distinct immunological pathomechanisms in immune-mediated neuroinflammatory diseases (imNDs) and immune-related adverse events (irAEs) of cancer immunotherapy.September 2024 – September 2028€1.000.000
Immunemonitoring UnitImmuno- & Cellular therapyThe primary objective of this project is to create an infrastructure to allow the integration of immune monitoring in clinical trials for cancer and neurological diseases at Adore.January 2025 – January 2026€1.252.000
Cell2sample
Biocomputation
The goal of this project is to establish a comprehensive computational framework that integrates diverse omics data types, including (single-cell) RNA/DNA sequencing and spatially resolved molecular data, available from both public sources and ongoing projects of Adore researchers.October 2025 – October 2029€688.000
Micro to macro (M2M)BiocomputationThe goal of this project is to develop computational techniques that bridge the microscale and macroscale in neurological and oncological diseases.July 2025 – July 2029€688.000
Building2UnderstandingBiocomputationThe ultimate aim of this project is to improve predictive models based on cell type-specific genetic properties.September 2025 – September 2029€688.000

CAVIR
Immuno- & Cellular therapyAdore supports this project that aims to understand the applicability of CAR-T technology in the context of neurodegenerative diseases.September 2024 – September 2027€20.000
Adore Clinical Trial SupportClinical ResearchAdore Clinical Trial Support (ACTS) is to strengthen the pipeline of therapeutic development in both Oncology and Neurology, by sharing resources, leveraging on each other’s expertise, and investing in staff that allows cross-discipline activities.September 2025 – September 2028€1.185.000
SENS-PHOSProteomics and GenomicsThe primary objective of the SENS-PHOS project is developing a high-throughput and sensitive (phospho)proteomics processing and analysis platform to enable basic and translational onco-neuroscience research on cellular signaling and its disturbances in dementia and personalized cancer treatment.April 2026 – October 2028 € 365.119
CRISPR Rise to the task Drug Discovery & Therapy Development The primary objective of CRISPR: Rise to the Task is to design, validate, and translate innovative CRISPR-based in vivo gene and genome therapies, addressing hereditary pediatric diseases, aggressive cancers, and Alzheimer’s disease.January 2026 – January 2031 2.500.000
CRISPR: Proof of ConceptProteomics & Genomics The CRISPR: Proof-of-Concept project aims to develop a new combinatorial CRISPR screening method that allows upscaling the number of genes that can be screened in combination. This new method could contribute to discovering weaknesses in cancer cells and developing novel therapies for neurodegenerative diseases.January 2026 – January 2027 €140.197 
SCONEProteomics & Genomics The SCONE project aims at providing a multilevel molecular (-omics) understanding of disease progression of cells in their specific environment. TBD€2.300.000 
SCAPEProteomics & Genomics The SCAPE project aims to establish a cutting-edge single-cell proteomics unit to advance oncology and neuroscience research by enabling high-resolution, quantitative protein analysis at the single-cell level. January 2026 – January 2031€1.850.000
CAR-TB-EXPLORE Immuno-/Cellular therapy To gain a better understanding of immunological mechanisms underlying the clinical effects of CD19 CAR T-cell therapy mediated B-cell depletion in patients with autoimmune inflammatory neurological disorders or lymphoma.TBD€1.981.851 
ORBITDrug Discovery & Therapy Development This project will combine the chemical expertise from AIMMS (VU) with the drug target expertise from the AUMC to identify three different therapies targeting protein-protein interactions relevant in cancer and Alzheimers disease. June 2026 – June 2030€1.291.625 
Survival SwitchProteomics and GenomicsThe aim is to identify novel therapeutic targets that regulate cell death and survival in Parkinson’s disease and colorectal cancer. The focus is on cell-type and disease condition specific protein interactors of anti and pro-apoptotic Bcl2-family members.TBD€97.508